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F5 BIG-IP LTM i2600 vs Cisco FPR-4120-K9: Application Delivery vs Next-Gen Firewall Comparison
Jun 24 , 2025 3

F5 BIG-IP LTM i2600 vs Cisco FPR-4120-K9: Application Delivery vs Next-Gen Firewall Comparison


F5-BIG-LTM-I2600 vs FPR-4120-K9


When evaluating network infrastructure components, the F5 BIG-IP LTM i2600 (application delivery controller) and Cisco FPR-4120-K9 (next-generation firewall) serve fundamentally different purposes in enterprise networks. This comprehensive comparison examines their technical specifications, operational capabilities, and ideal deployment scenarios to help network architects make informed purchasing decisions.

Technical Specifications Comparison

FeatureF5 BIG-IP LTM i2600Cisco FPR-4120-K9
Processor8-core 2.4 GHz16-core 3.2 GHz
System Memory32 GB DDR464 GB DDR4
Storage480 GB SSD960 GB SSD
Throughput Capacity12 Gbps25 Gbps
SSL/TLS Performance5 Gbps15 Gbps
Maximum Connections800,0001.2 million
Power Consumption150W (typical)280W (typical)
Network Interfaces8x 1/10G SFP+16x 1/10/25G SFP28

The FPR-4120-K9 demonstrates 2-3x greater performance metrics in security processing, while the BIG-IP LTM i2600 specializes in advanced application delivery capabilities.

Functional Capabilities Analysis

1. Core Functionality

  • F5 BIG-IP LTM i2600:

    • Advanced load balancing (Layer 4-7)

    • SSL/TLS acceleration

    • Application health monitoring

    • Web application firewall

    • DNS load balancing

  • FPR-4120-K9:

    • Stateful firewall inspection

    • Intrusion prevention system

    • Advanced malware protection

    • Application visibility and control

    • URL filtering and categorization

2. Security Features

Shared Capabilities:

  • SSL/TLS inspection

  • Basic firewall functionality

  • IP reputation filtering

BIG-IP LTM i2600 Advantages:

  • Advanced application persistence

  • Intelligent traffic management

  • iRules customization

  • Protocol optimization

FPR-4120-K9 Strengths:

  • Deep packet inspection

  • Integrated threat intelligence

  • Advanced malware analysis

  • Sandboxing capabilities

Physical Design Comparison

Chassis Architecture:

  • F5 BIG-IP LTM i2600:

    • 1RU compact form factor

    • Single power supply

    • Front-accessible ports

    • Optimized for data center deployment

  • FPR-4120-K9:

    • 2RU enterprise chassis

    • Redundant power options

    • Front/rear service access

    • Security-optimized design

Environmental Specifications:

  • Operating temperature:

    • Both: 0 to 40°C

  • Physical dimensions:

    • BIG-IP i2600: 1RU, 17.5" deep

    • FPR-4120: 2RU, 17.5" deep

  • Weight:

    • BIG-IP i2600: 20 lbs

    • FPR-4120: 28 lbs

User Experience Evaluation

Administration & Management:

  • F5 BIG-IP LTM i2600:

    • F5 Configuration utility

    • TMOS Shell (tmsh)

    • iControl REST API

    • Centralized management options

  • FPR-4120-K9:

    • Firepower Management Center

    • Cisco Defense Orchestrator

    • REST API/SDK access

    • Multi-device management

Operational Differences:

  • BIG-IP i2600 excels in:

    • Application traffic management

    • SSL optimization

    • Advanced load balancing

  • FPR-4120-K9 superior for:

    • Threat detection/prevention

    • Security policy enforcement

    • Network segmentation

Pricing & Total Cost Analysis

Acquisition Costs:

  • F5 BIG-IP LTM i2600: 35,00045,000

  • FPR-4120-K9: 45,00055,000

Operational Expenditures:

  • Power consumption difference: ~$150/year

  • Rack space requirements:

    • FPR-4120 needs 2x more space

  • Support contracts:

    • Both require premium licensing

Five-Year TCO Considerations:

  • BIG-IP i2600 justified for:

    • Application delivery needs

    • SSL-intensive environments

    • Advanced traffic management

  • FPR-4120-K9 economical for:

    • Comprehensive security

    • Enterprise threat prevention

    • Large-scale deployments

Power Efficiency Metrics

Power Specifications:

  • Input options:

    • Both support AC power

    • FPR-4120 offers DC option

  • Energy monitoring:

    • Both provide real-time metrics

Efficiency Comparison:

  • Performance per watt:

    • BIG-IP i2600: 80 Mbps/W

    • FPR-4120: 89 Mbps/W

  • Idle power draw:

    • BIG-IP i2600: 100W

    • FPR-4120: 150W

Compatibility & Ecosystem Integration

Third-Party Interoperability:

  • Both support:

    • SIEM integration

    • Cloud platforms

    • API-based automation

BIG-IP i2600 Enhanced Integration:

  • Kubernetes ingress controller

  • OpenStack integration

  • DevOps toolchains

  • iApps templates

FPR-4120-K9 Advantages:

  • Cisco SecureX platform

  • Advanced threat intelligence

  • SD-WAN security integration

Software Support & Lifecycle

Current Software Features:

  • F5 BIG-IP i2600:

    • TMOS 16.1+

    • Advanced traffic management

    • SSL insights

    • Cloud-native ADC

  • FPR-4120-K9:

    • Firepower 7.0+

    • Threat intelligence

    • Behavioral analytics

    • Cloud security

Security Updates:

  • Both receive:

    • Regular vulnerability patches

    • 5+ years of maintenance

  • FPR-4120-K9 offers:

    • Extended threat intelligence

    • Critical security updates

Future Roadmap:

  • BIG-IP i2600:

    • Enhanced cloud integration

    • Container support

    • Advanced analytics

  • FPR-4120-K9:

    • AI-driven security

    • Cloud-scale protection

    • Advanced threat prevention

Decision Framework

Select F5 BIG-IP LTM i2600 When:
✔ Application delivery focus
✔ Advanced load balancing needs
✔ SSL/TLS optimization
✔ Cloud-native deployments

Choose FPR-4120-K9 When:
✔ Comprehensive security required
✔ Enterprise threat prevention
✔ Network segmentation
✔ Cisco ecosystem integration

Key Selection Criteria:

  1. Primary workload (application delivery vs security)

  2. Performance requirements

  3. Existing infrastructure

  4. Budget constraints

The F5 BIG-IP LTM i2600 excels in application delivery and traffic management, while the FPR-4120-K9 provides superior security enforcement capabilities. These solutions are complementary rather than competitive in most enterprise environments.

Implementation Recommendation: For optimal performance and security, consider deploying both solutions in tandem - the BIG-IP i2600 handling application delivery and SSL offloading, while the FPR-4120-K9 provides deep security inspection. This layered approach delivers both application optimization and robust security protection.


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